Serum soluble interleukin 7 receptor is strongly associated with lupus nephritis in patients with systemic lupus erythematosus
Identifieur interne : 000360 ( Main/Exploration ); précédent : 000359; suivant : 000361Serum soluble interleukin 7 receptor is strongly associated with lupus nephritis in patients with systemic lupus erythematosus
Auteurs : Valérie Badot [Belgique] ; Remco K M A C. Luijten [Pays-Bas] ; Joel A. Van Roon [Pays-Bas] ; Geneviève Depresseux [Belgique] ; Selda Aydin [Belgique] ; Benoît J. Van Den Eynde [Belgique] ; Frédéric A. Houssiau [Belgique] ; Bernard R. Lauwerys [Belgique]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2013-03.
Abstract
Background The soluble form of the interleukin 7 receptor (sIL-7R) is produced by fibroblasts after stimulation with proinflammatory cytokines. Increased sIL-7R serum and synovial fluid levels were recently demonstrated in patients with rheumatoid arthritis. Objectives To investigate whether sIL-7R production is dysregulated in systemic lupus erythematosus (SLE), and whether this correlates with disease activity. Methods Serum and urine sIL-7R concentrations were measured by ELISA, and sIL-7R quantitative PCR (qPCR) studies were performed in peripheral blood mononuclear cells (PBMCs). IL-7R, tumour necrosis factor α (TNFα), IL-1β and IL-17 immunostainings were performed on kidney sections. Results sIL-7R concentrations were significantly higher in SLE sera than in controls, and correlated with SLE Disease Activity Index (SLEDAI) scores. Accordingly, serum sIL-7R levels were strongly raised in patients with nephritis. Moreover in patients with lupus nephritis, serum sIL-7R decreased upon treatment. sIL-7R gene expression in PBMCs was similar in patients with lupus nephritis and controls. By contrast, abundant perivascular IL-7R expression was seen in SLE kidney biopsy specimens, which was associated with expression of TNFα in the surrounding tissue. Conclusions Our data indicate that sIL-7R is a marker of SLE disease activity, especially nephritis. In contrast to conventional disease activity markers, sIL-7R is not produced by immune cells, but might instead reflect activation of tissue cells in the target organ.
Url:
DOI: 10.1136/annrheumdis-2012-202364
Affiliations:
- Belgique, Pays-Bas
- Région de Bruxelles-Capitale, Utrecht (province)
- Bruxelles, Utrecht
- Université catholique de Louvain
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Van Den Eynde</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Ludwig Institute for Cancer Research, Brussels Branch & de Duve Institute, Université catholique de Louvain, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université catholique de Louvain</orgName></affiliation></author><author><name sortKey="Houssiau, Frederic A" sort="Houssiau, Frederic A" uniqKey="Houssiau F" first="Frédéric A" last="Houssiau">Frédéric A. 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Increased sIL-7R serum and synovial fluid levels were recently demonstrated in patients with rheumatoid arthritis. Objectives To investigate whether sIL-7R production is dysregulated in systemic lupus erythematosus (SLE), and whether this correlates with disease activity. Methods Serum and urine sIL-7R concentrations were measured by ELISA, and sIL-7R quantitative PCR (qPCR) studies were performed in peripheral blood mononuclear cells (PBMCs). IL-7R, tumour necrosis factor α (TNFα), IL-1β and IL-17 immunostainings were performed on kidney sections. Results sIL-7R concentrations were significantly higher in SLE sera than in controls, and correlated with SLE Disease Activity Index (SLEDAI) scores. Accordingly, serum sIL-7R levels were strongly raised in patients with nephritis. Moreover in patients with lupus nephritis, serum sIL-7R decreased upon treatment. sIL-7R gene expression in PBMCs was similar in patients with lupus nephritis and controls. By contrast, abundant perivascular IL-7R expression was seen in SLE kidney biopsy specimens, which was associated with expression of TNFα in the surrounding tissue. Conclusions Our data indicate that sIL-7R is a marker of SLE disease activity, especially nephritis. In contrast to conventional disease activity markers, sIL-7R is not produced by immune cells, but might instead reflect activation of tissue cells in the target organ.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Pays-Bas</li></country><region><li>Région de Bruxelles-Capitale</li><li>Utrecht (province)</li></region><settlement><li>Bruxelles</li><li>Utrecht</li></settlement><orgName><li>Université catholique de Louvain</li></orgName></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Badot, Valerie" sort="Badot, Valerie" uniqKey="Badot V" first="Valérie" last="Badot">Valérie Badot</name></region><name sortKey="Aydin, Selda" sort="Aydin, Selda" uniqKey="Aydin S" first="Selda" last="Aydin">Selda Aydin</name><name sortKey="Badot, Valerie" sort="Badot, Valerie" uniqKey="Badot V" first="Valérie" last="Badot">Valérie Badot</name><name sortKey="Depresseux, Genevieve" sort="Depresseux, Genevieve" uniqKey="Depresseux G" first="Geneviève" last="Depresseux">Geneviève Depresseux</name><name sortKey="Houssiau, Frederic A" sort="Houssiau, Frederic A" uniqKey="Houssiau F" first="Frédéric A" last="Houssiau">Frédéric A. Houssiau</name><name sortKey="Lauwerys, Bernard R" sort="Lauwerys, Bernard R" uniqKey="Lauwerys B" first="Bernard R" last="Lauwerys">Bernard R. Lauwerys</name><name sortKey="Van Den Eynde, Benoit J" sort="Van Den Eynde, Benoit J" uniqKey="Van Den Eynde B" first="Benoît J" last="Van Den Eynde">Benoît J. Van Den Eynde</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Luijten, Remco K M A C" sort="Luijten, Remco K M A C" uniqKey="Luijten R" first="Remco K M A C" last="Luijten">Remco K M A C. Luijten</name></region><name sortKey="Van Roon, Joel A" sort="Van Roon, Joel A" uniqKey="Van Roon J" first="Joel A" last="Van Roon">Joel A. Van Roon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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